|
KMID : 1123920040180020561
|
|
Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 2 p.561 ~ p.570
|
|
|
Study on the Effect of Gamissanghwa-tang and each Medicinal Plant Extract for the Hair Growth of the Mice using In vivo and In vitro Test
|
|
Yun Jeong-Hun
Kim Nam-Kwen
Lim Kyu-Sang
Roh Seok-Sun
Hwang Choong-Yeon
|
|
|
Abstract
|
|
|
|
To screen the effective materials for hair loss treatment, the Gamissanghwa-tang extracts were tested. As a result we found that the Gamissanghwa-tang extracts have the hair growth promoting effect. After topical application of each test materials to the back of CS7BL/6 mice, the earlier conversion of telogen-to-anagen phase was induced. In the experiments of 5α-reductase type II inhibition assay, Radix Paeoniae Alba, Semen Cuscutae showed effective potential to inhibit the activity of 5α-reductase type II. And hair growth index of the Gamissanghwa-tang extracts ranked as 1.2, especially the hair growth index of Fructus Rubi is highest as 1.8. But there were no plant extracts which have effect on the DNA proliferation of hair dermal papilla cell measured by [³H]thymidine incorporation, the expression of growth factors such as IGF-I, KGF, HGF estimated by RT-PCR and protein synthesis of vibrissae hair follicle measured by [/sup 35/S] cysteine incorporation. Cortex Cinnamomi showed anti-bacterial effect on P. ovale, Radix Paeoniae Alba has the highest radical scavening activity and Radix Glycyrrhizae has the highest effects of NO synthesis. These results suggest that Gamissanghwa-tang can be used as a potent treatment agent for helping hair growth stimulation.
|
|
|
KEYWORD
|
|
|
Gamissanghwa-tang(加味雙和湯), hair loss, hair growth stimulation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|